Necrosis VS Apoptosis, six major differences
Necrosis VS Apoptosis, visual maps and quick details on 6 major differences in cell death by necrosis and apoptosis for basic pathology knowledge. In this week I will post about cell death and adaptations. Hope u enjoy reading these main differences, and subscribe for updates.
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Necrosis VS Apoptosis
There are 6 major differences in Necrosis and Apoptosis.
- Cell death reasons- Necrosis is always pathological, which means cell death happens because of unfavorable stressful situations (infections, excessive heat, radiation or lack of blood supply). Apoptosis is most commonly physiological; it is programmed cell death which eliminates unwanted cells from the body. Sometimes apoptosis happens in cells with damaged DNA.
- Cell Size- Cell size increases in Necrosis and cell Shrinks in Apoptosis.
- Nucleus- In Necrosis nucleus undergo pyknosis, fragmentation and karyolysis. Apoptotic nucleus breaks into nucleosome size fragments.
- Plasma membrane- there is loss of plasma membrane integrity in necrosis, but plasma membrane remains intact in apoptosis.
- Cellular contents- In necrosis there is leakage of cellular contents
- Adjacent Inflammation- Because there is Plasma membrane rupture there is leakage of contents which attracts inflammatory cells, so there is inflammation in necrosis. Apoptotic bodies are phagocytosed so there is no cellular material to induce inflammation hence there is no inflammation in Apoptosis.
Further reading https://www.diffen.com/difference/Apoptosis_vs_Necrosis
Revise Anthrax and also note that there is necrosis in black eschar formation, the toxins of anthrax bacillus causes cell death by necrosis, https://creativemeddoses.com/topics-list/anthrax-diagnosis-and-treatment/
Stay tuned for more on general pathology updates.